Jindal S K, Ramasubramanian V, Behera D
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh.
Indian J Med Res. 1994 Aug;100:77-80.
Normal i.e., chance variations in spirometry were evaluated in 80 healthy Indian adults by the measurement of base-line spirometric indices (FVC, FEV1 and FEF25-75%) and the per cent changes following placebo administration of aerosolized saline. There was a mean per cent change of 0.7, 0.4 and 0.3 per cent over the base-line values in FVC, FEV1 and FEF25-75% respectively following placebo inhalation. The cut off responses for 95 per cent confidence limits were 11.2 per cent for FVC and 12.7 per cent for FEV1 following placebo inhalation. Since the test sample represents a healthy Indian population, a per cent change greater than 12.7 per cent in FEV1 is more than that observed in 95 per cent of healthy Indians. It is suggested that for both delta FEV1 per cent and delta FVC per cent, the lower limit should be fixed at more than 15 per cent to define 'abnormality' in clinical practice.
通过测量基线肺量计指标（用力肺活量（FVC）、第一秒用力呼气容积（FEV1）和25%-75%用力呼气流量（FEF25-75%））以及雾化盐水安慰剂给药后的百分比变化，对80名健康印度成年人的正常肺量计变化即随机变异进行了评估。安慰剂吸入后，FVC、FEV1和FEF25-75%相对于基线值的平均百分比变化分别为0.7%、0.4%和0.3%。安慰剂吸入后，FVC的95%置信限的截断反应为11.2%，FEV1为12.7%。由于测试样本代表健康的印度人群，FEV1中大于12.7%的百分比变化超过了95%健康印度人的观察值。建议在临床实践中，对于FEV1百分比变化量（delta FEV1%）和FVC百分比变化量（delta FVC%），下限应设定为超过15%以定义“异常”。
