Datta C, Gupta J, Sengupta D
Department of Biochemistry, University of Calcutta.
Indian J Med Res. 1994 Aug;100:87-9.
The organophosphorus insecticides phosphamidon and malathion were found to inhibit the activity of human acetylcholinesterase in vitro, in the human erythrocyte membrane. Lineweaver-Burk analysis indicated that the insecticide induced inhibition of acetylcholinesterase activity was uncompetitive in nature. The total lipid, cholesterol and phospholipid contents of erythrocyte membranes were reduced following phosphamidon and technical malathion treatment, while the level of lipid peroxidation was raised following malathion treatment.
研究发现，有机磷杀虫剂磷胺和马拉硫磷在体外可抑制人红细胞膜中乙酰胆碱酯酶的活性。Lineweaver-Burk分析表明，杀虫剂对乙酰胆碱酯酶活性的抑制本质上属于非竞争性抑制。经磷胺和工业用马拉硫磷处理后，红细胞膜中的总脂质、胆固醇和磷脂含量降低，而经马拉硫磷处理后，脂质过氧化水平升高。
