Sumners C, Tang W, Paulding W, Raizada M K
Department of Physiology, College of Medicine, University of Florida, Gainesville 32610.
Glia. 1994 Jun;11(2):110-6. doi: 10.1002/glia.440110206.
Astroglial cells derived from the mammalian central nervous system contain a wide variety of peptide receptors, including specific sites for angiotensin II (AII) and atrial natriuretic peptide (ANP). The AII receptors present in these cells are primarily of the AT1 subtype. The ANP receptors present in these cells consist of a mix of ANP-A and ANP-B sites ("biological receptors") and also ANP-C sites ("clearance receptors"). Available evidence indicates that activation of AII receptors results in a stimulation of astroglial proliferation, whereas ANP has an antiproliferative effect in these cells. Intracellular pathways which may mediate these effects of AII and ANP on cell proliferation are discussed, including the presentation of novel data on the activation of protein kinase C and of glucose uptake by AII. We also consider the possibility that the opposing actions of AII and ANP on astroglial proliferation may represent another facet of the mutual antagonism between these two peptides, which has been observed throughout mammalian systems.
源自哺乳动物中枢神经系统的星形胶质细胞含有多种肽受体，包括血管紧张素II（AII）和心钠素（ANP）的特异性结合位点。这些细胞中存在的AII受体主要是AT1亚型。这些细胞中存在的ANP受体由ANP-A和ANP-B位点（“生物受体”）以及ANP-C位点（“清除受体”）混合组成。现有证据表明，AII受体的激活会刺激星形胶质细胞增殖，而ANP在这些细胞中具有抗增殖作用。本文讨论了可能介导AII和ANP对细胞增殖作用的细胞内信号通路，包括关于AII激活蛋白激酶C和葡萄糖摄取的新数据。我们还考虑了AII和ANP对星形胶质细胞增殖的相反作用可能代表这两种肽之间相互拮抗的另一个方面的可能性，这种拮抗作用在整个哺乳动物系统中都已被观察到。
