严重疟疾感染啮齿动物模型中的低血糖和高胰岛素血症。
Hypoglycemia and hyperinsulinemia in rodent models of severe malaria infection.
作者信息
Elased K, Playfair J H
机构信息
Department of Immunology, University College London Medical School, United Kingdom.
出版信息
Infect Immun. 1994 Nov;62(11):5157-60. doi: 10.1128/iai.62.11.5157-5160.1994.
Abstract
Severe hypoglycemia developed during nonlethal Plasmodium chabaudi and lethal P. yoelii blood stage malaria infection in mice, always in association with hyperinsulinemia. Supernatants of lethal P. yoelii incubated overnight induced hypoglycemia and hyperinsulinemia in normal mice. In murine malaria, hypoglycemia may be largely secondary to increased insulin secretion.
摘要
在小鼠感染非致死性查巴迪疟原虫和致死性约氏疟原虫血期疟疾期间会出现严重低血糖，且总是伴有高胰岛素血症。将致死性约氏疟原虫的培养上清液孵育过夜可诱导正常小鼠出现低血糖和高胰岛素血症。在鼠疟中，低血糖可能很大程度上继发于胰岛素分泌增加。
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