Sabourin J C, Martin A, Baruch J, Truc J B, Gompel A, Poitout P
Department of Pathology, Henri Mondor Hospital, Créteil, France.
Int J Cancer. 1994 Oct 1;59(1):1-6. doi: 10.1002/ijc.2910590102.
bcl-2 is a proto-oncogene discovered through the t(14;18) translocation occurring in most human follicular lymphomas. The function so far attributed to bcl-2 is to counteract the occurrence of apoptosis and to prolong cell survival without affecting the cycling cells. Apoptosis has been described in normal breast tissue epithelial cells, and it peaks at the end of the luteal phase. We have studied bcl-2 expression by an immunohistochemical method in 50 samples of normal breast tissue distributed throughout the menstrual cycle. bcl-2 staining predominated in the lobular epithelial cells. It displayed a striking cyclic variation, with maximal expression at the mid-cycle period and a sharp decrease at the end of the cycle. These results strongly suggest that the regulation of bcl-2 expression in breast tissue is hormone-dependent. This could be of significance in tumorigenesis.
bcl-2是一种原癌基因，通过发生在大多数人类滤泡性淋巴瘤中的t(14;18)易位而被发现。迄今为止，归因于bcl-2的功能是对抗细胞凋亡的发生并延长细胞存活时间，而不影响细胞周期。细胞凋亡已在正常乳腺组织上皮细胞中被描述，并且在黄体期结束时达到峰值。我们通过免疫组织化学方法研究了在整个月经周期分布的50个正常乳腺组织样本中bcl-2的表达。bcl-2染色在小叶上皮细胞中占主导。它呈现出显著的周期性变化，在周期中期表达最高，而在周期结束时急剧下降。这些结果强烈表明乳腺组织中bcl-2表达的调节是激素依赖性的。这在肿瘤发生中可能具有重要意义。
