Jacquemier J, Adelaide J, Parc P, Penault-Llorca F, Planche J, deLapeyriere O, Birnbaum D
Département d'Anatomo-Pathologie, Institut Paoli-Calmettes, Marseille, France.
Int J Cancer. 1994 Nov 1;59(3):373-8. doi: 10.1002/ijc.2910590314.
Fibroblast growth factors (FGF) constitute a family of at least 9 members which act through high-affinity tyrosine-kinase receptors encoded by 4 distinct genes. In humans, the FGFR1 gene is located in chromosomal region 8p12. Its amplification and expression were examined in a panel of 110 breast carcinoma samples by Southern- and Northern-blot analyses. FGFR1 was amplified in 9% and overexpressed in about 15% of the tumors studied. In situ hybridization experiments were performed on tissue sections of normal breast and tumors with a high level of FGFR1 expression. In both normal and tumoral tissues, FGFR1 RNA was detected in the epithelial cells. Overexpression of FGFR1 seems to be associated with small, well-differentiated diploid tumors.
成纤维细胞生长因子（FGF）构成了一个至少有9个成员的家族，它们通过由4个不同基因编码的高亲和力酪氨酸激酶受体发挥作用。在人类中，FGFR1基因位于染色体区域8p12。通过Southern印迹和Northern印迹分析，在一组110个乳腺癌样本中检测了其扩增和表达情况。在所研究的肿瘤中，9%的样本中FGFR1发生了扩增，约15%的样本中FGFR1过表达。对正常乳腺组织切片和FGFR1高表达的肿瘤组织进行了原位杂交实验。在正常组织和肿瘤组织中，上皮细胞中均检测到FGFR1 RNA。FGFR1的过表达似乎与小的、高分化的二倍体肿瘤有关。
