Parant M
Laboratoire d'Immunopharmacologie, CNRS & Université Paris, France.
Int J Immunopharmacol. 1994 May-Jun;16(5-6):445-9. doi: 10.1016/0192-0561(94)90034-5.
Among the numerous synthetic compounds of the MDP series capable of acting as adjuvants of vaccines, some can also stimulate the resistance of mice to experimental bacterial infections when given alone as a single dose before the challenge. This increase in nonspecific resistance appears to be mainly related to a priming effect on phagocytic cells leading to an enhancement in responses to the bacterial challenge, such as bactericidal activity and release of cytokines. The mediators produced by monocytes and macrophages (TNF, IL-1) are known to exert a protective effect when given early at the beginning of infection. Moreover, TNF and muramyl peptides could exert a synergistic activity against a bacterial or fungal challenge.
在众多能够充当疫苗佐剂的MDP系列合成化合物中，有些化合物在攻击前单独作为单剂量给药时，也能刺激小鼠对实验性细菌感染的抵抗力。这种非特异性抵抗力的增强似乎主要与对吞噬细胞的启动作用有关，从而导致对细菌攻击的反应增强，如杀菌活性和细胞因子的释放。已知单核细胞和巨噬细胞产生的介质（TNF、IL-1）在感染开始时早期给予时具有保护作用。此外，TNF和胞壁酰肽对细菌或真菌攻击可能具有协同活性。
