Fazzini P F, Marchi F, Pucci P
Acta Cardiol. 1978;33(1):25-9.
In 8 patients affected with acute myocardial infarction verapamil was highly effective in controlling ventricular extrasystoles. Theoretically the drug ought not to be effective if the extrasystoles were related to fast cardiac fibers characterized by a rapid inward Na+ current. The result suggests that in acute myocardial ischemia ventricular extrasystoles are related to slow inward Ca++ currents.
在8例急性心肌梗死患者中，维拉帕米在控制室性期前收缩方面非常有效。从理论上讲，如果期前收缩与以快速内向钠离子电流为特征的快心肌纤维有关，那么该药应该无效。结果表明，在急性心肌缺血时，室性期前收缩与缓慢内向钙离子电流有关。
