Fazzini P F, Marchi F, Pucci P
G Ital Cardiol. 1977;7(10):940-3.
In 12 patients affected by acute myocardial infarction complicated only by ventricular extrasystoles, verapamil was highly effective in the control of the arrhythmias. This result is in agreement with the experimental finding that ischemia inactivates partially or totally early Na+ inward currents, so that fast fibers become slow fibers. The efficacy of verapamil stresses the importance of these fibers which have acquired a slow response in the genesis of arrhythmias due to acute coronary attacks and opens interesting therapeutical prospects.
在12例仅合并室性期前收缩的急性心肌梗死患者中，维拉帕米在控制心律失常方面非常有效。这一结果与实验发现一致，即缺血会部分或完全使早期钠内向电流失活，从而使快纤维变为慢纤维。维拉帕米的疗效强调了这些在急性冠状动脉发作所致心律失常发生过程中获得慢反应的纤维的重要性，并开启了有趣的治疗前景。
