Valentine B A, Rousselle S D, Sams A E
Department of Pathology, College of Veterinary Medcine, Cornell University, Ithaca, NY 14853-6401.
J Am Vet Med Assoc. 1994 Jul 15;205(2):332-6.
Three horses with fibrotic myopathy were examined for neuromuscular disease. In 2 horses, concentric needle electromyography was performed. Dense spontaneous activity suggestive of denervation, was found in multiple thigh muscles of 1 of the 2 horses. All 3 horses were euthanatized. Histochemical and histologic examination of tissue specimens was performed. All horses had degenerative lesions in peripheral and intramuscular nerves. Angular atrophy of type-1 and type-2 muscle fibers, indicative of denervation atrophy, was seen in multiple muscle specimens from all 3 horses. One horse was found to have a fracture of the greater trochanter, with fibrous entrapment of the sciatic nerve at that site. The cause of the peripheral neuropathy was not determined in the other 2 horses. It was concluded that peripheral neuropathy should be considered in horses with fibrotic myopathy.
对3匹患有纤维化肌病的马进行了神经肌肉疾病检查。对其中2匹马进行了同心针电极肌电图检查。在2匹马中的1匹马的多条大腿肌肉中发现了提示去神经支配的密集自发活动。所有3匹马均实施了安乐死。对组织标本进行了组织化学和组织学检查。所有马匹的外周神经和肌内神经均有退行性病变。在所有3匹马的多个肌肉标本中均可见1型和2型肌纤维的角形萎缩，提示去神经支配性萎缩。发现1匹马的大转子骨折，坐骨神经在该部位被纤维组织包绕。另外2匹马的外周神经病变原因未明确。得出的结论是，患有纤维化肌病的马匹应考虑外周神经病变。
