Step D L, Cummings J F, de Lahunta A, Valentine B A, Summers B A, Rowland P H, Mohammed H O, Eckerlin R H, Rebhun W C
Department of Large Animal Medicine, School of Veterinary Medicine, University of Wisconsin, Madison 53706.
J Am Vet Med Assoc. 1993 Jan 1;202(1):86-8.
A 9-year-old Quarter Horse mare was examined because of progressive weight loss, weakness, muscle atrophy and tremors, and behavioral change. Selenium and glutathione peroxidase assays, blood lead analysis, erythrocyte transketolase analysis, pseudorabies and Borrelia burgdorferi serology, electromyography, and CSF analysis were performed. Motor neuron degeneration was diagnosed by microscopic examination of neural tissues. The cause of the disease was not substantiated, but several possibilities were excluded via diagnostic testing. Diagnosis of motor neuron degeneration in horses may be made from an accurate history, thorough neurologic examination, and ancillary testing. In particular, antemortem diagnosis may be based on finding scattered angular atrophy of predominantly type-1 or of type-1 and -2 skeletal muscle fibers in frozen sections of muscle biopsy specimens.
一匹9岁的夸特马母马因体重逐渐减轻、虚弱、肌肉萎缩和震颤以及行为改变而接受检查。进行了硒和谷胱甘肽过氧化物酶检测、血铅分析、红细胞转酮醇酶分析、伪狂犬病和伯氏疏螺旋体血清学检测、肌电图检查以及脑脊液分析。通过对神经组织的显微镜检查诊断为运动神经元变性。疾病的病因未得到证实，但通过诊断测试排除了几种可能性。马运动神经元变性的诊断可基于准确的病史、全面的神经系统检查和辅助检测。特别是，生前诊断可能基于在肌肉活检标本的冰冻切片中发现主要为1型或1型和2型骨骼肌纤维的散在角形萎缩。
