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番红菌素，一种来自番红软骨霉（粘细菌）的新型电子传递抑制剂。生产、分离、理化性质及生物学特性

Crocacin, a new electron transport inhibitor from Chondromyces crocatus (myxobacteria). Production, isolation, physico-chemical and biological properties.

作者信息

Kunze B, Jansen R, Höfle G, Reichenbach H

机构信息

GBF, Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, FRG.

出版信息

J Antibiot (Tokyo). 1994 Aug;47(8):881-6. doi: 10.7164/antibiotics.47.881.

DOI:10.7164/antibiotics.47.881
PMID:7928674
Abstract

Crocacin was isolated from the biomass of the myxobacterium Chondromyces crocatus, strain Cm c3. It inhibited the growth of a few Gram-positive bacteria and a wide spectrum of yeasts and molds. In beef heart submitochondrial particles, crocacin blocked the electron transport within the bc1-segment (complex III) and caused a red shift in the reduced spectrum of cytochrome b with a maximum at 569 nm.

摘要

番红菌素是从粘细菌鳄鱼软骨霉（Chondromyces crocatus）菌株Cm c3的生物质中分离出来的。它能抑制一些革兰氏阳性细菌以及多种酵母和霉菌的生长。在牛心亚线粒体颗粒中，番红菌素会阻断bc1段（复合体III）内的电子传递，并导致细胞色素b还原光谱出现红移，最大红移波长为569纳米。

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