5-表海藻糖唑啉（海藻糖他汀）的合成。

Synthesis of 5-epi-trehazolin (trehalostatin).

作者信息

Kobayashi Y, Miyazaki H, Shiozaki M, Haruyama H

机构信息

Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1994 Aug;47(8):932-8. doi: 10.7164/antibiotics.47.932.

DOI:10.7164/antibiotics.47.932

PMID:7928681

Abstract

Synthesis of 5-epi-trehazolin (trehalostatin) (2) was accomplished via the crucial intermediate, epoxide (6 alpha), from D-glucose. The stereochemistry of epoxide (6 alpha) and its isomer (6 beta) which were obtained from Sharpless epoxidation, was determined by comparison between the NMR relaxation times of relevant protons.

摘要

5-表-海藻糖素（海藻糖他汀）（2）的合成是通过关键中间体环氧化合物（6α）从D-葡萄糖完成的。通过比较相关质子的核磁共振弛豫时间，确定了通过夏普莱斯环氧化反应得到的环氧化合物（6α）及其异构体（6β）的立体化学。