Clemensen P, Christensen P, Norsk P, Grønlund J
Department of Research and Development, Innovision, Odense, Denmark.
J Appl Physiol (1985). 1994 Jun;76(6):2832-9. doi: 10.1152/jappl.1994.76.6.2832.
The feasibility of replacing a conventional mass spectrometer (MS) with a specially modified multicomponent (O2, CO2, Freon 22, and SF6) acoustic infrared and paramagnetic (IR/PM) gas analyzer in inert gas-rebreathing and metabolic gas exchange measurements has been investigated. Rebreathing variables were determined simultaneously with the MS and IR/PM analyzers in duplicate measurements at rest and during submaximal exercise in 10 subjects. The differences (means +/- SD, IR/PM - MS) were 0.028 +/- 0.048 liters [functional residual capacity (FRC)], 0.18 +/- 0.38 l/min [cardiac output (Qc)], -0.006 +/- 0.030 l/min [O2 consumption (VO2)], and -33 +/- 108 ml [combined lung tissue and capillary blood volume (Vti,c)]. The coefficients of variation on repeated estimates were 5.8% (FRC), 5.4% (Qc), 6.2% (VO2), and 17% (Vti,c) with the IR/PM analyzer and 5.9% (FRC), 4.2% (Qc), 5.0% (VO2), and 9.8% (Vti,c) with the MS. The differences (IR/PM - MS) obtained in mixed-expirate measurements were -0.006 +/- 0.020 l/min (VO2) and 0.020 +/- 0.021 l/min (CO2 production). Breath-by-breath estimates of VO2 and CO2 production with the IR/PM analyzer were, on average, 2.4 and 4.4% higher than the MS estimates, respectively. Our results demonstrate that the IR/PM gas analyzer, when appropriately modified, can substitute for a complex MS in a variety of noninvasive pulmonary gas exchange measurements.
研究了在惰性气体再呼吸和代谢气体交换测量中，用经过特殊改装的多组分（氧气、二氧化碳、氟利昂22和六氟化硫）声学红外和顺磁（IR/PM）气体分析仪替代传统质谱仪（MS）的可行性。在10名受试者静息和次最大运动时，使用MS和IR/PM分析仪同时进行重复测量，以确定再呼吸变量。差异（均值±标准差，IR/PM - MS）为0.028±0.048升[功能残气量（FRC）]、0.18±0.38升/分钟[心输出量（Qc）]、-0.006±0.030升/分钟[耗氧量（VO2）]和-33±108毫升[肺组织和毛细血管血容量总和（Vti,c）]。使用IR/PM分析仪时，重复估计的变异系数分别为5.8%（FRC）、5.4%（Qc）、6.2%（VO2）和17%（Vti,c），使用MS时分别为5.9%（FRC）、4.2%（Qc）、5.0%（VO2）和9.8%（Vti,c）。在混合呼出气体测量中获得的差异（IR/PM - MS）为-0.006±0.020升/分钟（VO2）和0.020±0.021升/分钟（二氧化碳产生量）。使用IR/PM分析仪逐次呼吸估计的VO2和二氧化碳产生量平均分别比MS估计值高2.4%和4.4%。我们的结果表明，经过适当改装的IR/PM气体分析仪可以在各种无创肺气体交换测量中替代复杂的MS。
