Vandevyver C, Stinissen P, Cassiman J J, Raus J
Department of Immunology/Biotechnology, Dr. L. Willems-Instituut, Diepenbeek, Belgium.
J Neuroimmunol. 1994 Oct;54(1-2):35-40. doi: 10.1016/0165-5728(94)90228-3.
Multiple sclerosis (MS) is known to be associated with HLA-DR2, but it is possible that additional major histocompatibility complex (MHC) genes confer disease susceptibility. The most recent candidate genes for MHC-encoded susceptibility are the TAP genes, which are located between the HLA-DQ and DP loci, and encode for proteins believed to transport antigenic peptides from the cytoplasm into the endoplasmic reticulum. We studied TAP 1 and TAP 2 gene polymorphisms in 65 chronic progressive MS patients and 66 healthy subjects. No significant differences in the frequencies of TAP polymorphisms were observed between both groups. These data suggest that TAP is not a susceptibility gene for MS and that the disease-predisposing haplotype does not extend as far as TAP.
已知多发性硬化症（MS）与HLA - DR2相关，但可能还有其他主要组织相容性复合体（MHC）基因赋予疾病易感性。MHC编码易感性的最新候选基因是TAP基因，其位于HLA - DQ和DP基因座之间，编码的蛋白质被认为可将抗原肽从细胞质转运到内质网中。我们研究了65例慢性进展型MS患者和66名健康受试者的TAP 1和TAP 2基因多态性。两组之间未观察到TAP多态性频率的显著差异。这些数据表明，TAP不是MS的易感基因，且疾病易感单倍型并不延伸至TAP。
