Fox R A, MacSween J M, McGuire R L
Scand J Immunol. 1976;5(8):941-7. doi: 10.1111/j.1365-3083.1976.tb03045.x.
Soluble blood group substances, with human H and A activity, have previously been shown to block the interaction between guinea pig peritoneal macrophages and migration inhibition factor from fetal calf serum (FCS-MIF). Conversely, incubation of macrophages at 37 degrees C for 1 h in the presence of 0.1% blood group substance, followed by thorough washing, potentiates the action of FCS-MIF. The sensitivity of the macrophages is markedly increased, allowing detection of subthreshold levels of FCS-MIF. Blood group substances (BGS) labeled with radioidine are taken up by macrophages, and a proportion remains on the surface. This radiolabeled BGS is lost from the surface spontaneously, and the rate of loss is increased by treatment with trypsin. It is suggested that the BGS mimic the natural macrophage receptor for FCS-MIF and potentiate its effect by incorporating new receptors into the macrophage membrane.
先前已表明，具有人H和A活性的可溶性血型物质可阻断豚鼠腹腔巨噬细胞与胎牛血清迁移抑制因子（FCS-MIF）之间的相互作用。相反，在0.1%血型物质存在的情况下，将巨噬细胞在37℃孵育1小时，然后彻底洗涤，可增强FCS-MIF的作用。巨噬细胞的敏感性显著增加，从而能够检测到低于阈值水平的FCS-MIF。用放射性碘标记的血型物质（BGS）可被巨噬细胞摄取，一部分保留在表面。这种放射性标记的BGS会自发地从表面丢失，用胰蛋白酶处理会增加丢失速率。有人提出，BGS模拟了FCS-MIF的天然巨噬细胞受体，并通过将新受体整合到巨噬细胞膜中来增强其作用。
