Roy U K, Pan S
Department of Obstetrics and Gynaecology, Sambhunath Pandit Hospital, Calcutta.
J Indian Med Assoc. 1994 Jun;92(6):188-91.
Forty-six nulliparous women in third trimester of pregnancy with a raised blood pressure of 30 mm Hg (systolic) or/and 15 mm Hg (diastolic) or both, over baseline values were treated with 75 mg of aspirin per day. The results are compared with another 48 age, height, weight, and gestational period matched nulliparaous women with similar condition for trial selection, who were treated as control. There is considerable more number of cases in the control group than in aspirin treated group showing subsequent rise of BP, appearance of proteinuria, and severe pre-eclamptic toxaemia. The aspirin treated group showed increased mean gestational age at termination 39.4 +/- 2.6 weeks as against 38.2 +/- 3.4, increased foetal weight 2860 +/- 552 g as against 2540 +/- 720 g. No case of neonatal haemorrhagic manifestations or congenital malformations were seen. However not much result is obtained with aspirin therapy in cases with established pregnancy induced hypertension or with proteinuria. Hence it is concluded that aspirin therapy should be given to prevent pregnancy induced hypertension. As predictability of other screening tests are not unequivocal, criterion used in this series for screening may be used.
46名妊娠晚期未生育的女性，其血压较基线值收缩压升高30 mmHg或/和舒张压升高15 mmHg或两者均升高，每天接受75 mg阿司匹林治疗。将结果与另外48名年龄、身高、体重和孕周匹配的未生育女性进行比较，这些女性因试验选择条件相似而作为对照组接受治疗。对照组中出现血压随后升高、蛋白尿出现以及重度先兆子痫中毒的病例数量比阿司匹林治疗组多得多。阿司匹林治疗组的平均终止妊娠孕周增加，为39.4±2.6周，而对照组为38.2±3.4周；胎儿体重增加，为2860±552 g，而对照组为2540±720 g。未观察到新生儿出血表现或先天性畸形的病例。然而，对于已确诊的妊娠高血压或蛋白尿病例，阿司匹林治疗并未取得太多效果。因此得出结论，应给予阿司匹林治疗以预防妊娠高血压。由于其他筛查试验的可预测性并不明确，本系列中用于筛查的标准可被采用。
