吉兰-巴雷综合征患者对空肠弯曲菌和神经节苷脂的血清反应性。

Seroreactivity to Campylobacter jejuni and gangliosides in patients with Guillain-Barré syndrome.

作者信息

von Wulffen H, Hartard C, Scharein E

机构信息

Institut für Medizinische Mikrobiologie und Immunologie, University Hospital Eppendorf, Hamburg, Germany.

出版信息

J Infect Dis. 1994 Oct;170(4):828-33. doi: 10.1093/infdis/170.4.828.

DOI:10.1093/infdis/170.4.828

PMID:7930724

Abstract

Seroreactivities to Campylobacter jejuni or Campylobacter coli and to the gangliosides GM1 and GD1b were studied by quantitative and immunoglobulin class-specific ELISAs in 42 patients with recent onset of acute Guillain-Barré syndrome (GBS), in 39 patients with positive Campylobacter serology but no neurologic disease, and in 52 healthy blood donors. GBS patients showed positive reactivities to C. jejuni in 57%, 26%, and 2% for IgG, IgA, and IgM, respectively, while blood donors had corresponding values of 6%, 2%, and 4%. IgG, IgA, and IgM reactivities to GM1 were 48%, 78%, and 56% for GBS patients and 4%, 2%, and 4% for blood donors, respectively. Reactivities to GD1b were 77%, 51%, and 15% for the GBS group and 2%, 8%, and 8% for the blood donors, respectively. Patients with positive Campylobacter serology but no neurologic disease also had antibodies to GM1 and GD1b in over half of the cases. Increased titers to C. jejuni closely correlated with increased titers to GM1 and GD1b.

摘要

通过定量和免疫球蛋白类别特异性酶联免疫吸附测定（ELISA），对42例近期发病的急性吉兰-巴雷综合征（GBS）患者、39例弯曲杆菌血清学阳性但无神经疾病的患者以及52名健康献血者，研究了针对空肠弯曲杆菌或结肠弯曲杆菌以及神经节苷脂GM1和GD1b的血清反应性。GBS患者中，IgG、IgA和IgM对空肠弯曲杆菌的反应性阳性率分别为57%、26%和2%，而献血者的相应值分别为6%、2%和4%。GBS患者对GM1的IgG、IgA和IgM反应性分别为48%、78%和56%，献血者分别为4%、2%和4%。GBS组对GD1b的反应性分别为77%、51%和15%，献血者分别为2%、8%和8%。弯曲杆菌血清学阳性但无神经疾病的患者中，超过半数的病例也有针对GM1和GD1b的抗体。空肠弯曲杆菌滴度升高与GM1和GD1b滴度升高密切相关。