Gion M, Mione R, Becciolini A, Balzi M, Correale M, Piffanelli A, Giovannini G, Saccani Jotti G, Fontanesi M
Center for the Study of Biological Markers of Malignancy, General Hospital, Venezia, Italy.
Int J Biol Markers. 1994 Apr-Jun;9(2):109-14. doi: 10.1177/172460089400900208.
The serological tumor marker tissue polypeptide antigen (TPA) and the more recently identified tissue-specific polypeptide antigen (TPS) have been reported to be indicators of the proliferation rate of the tumor. In the present investigation we compared the cytosol level of the two markers with the proliferative activity of the tumor measured using the 3H-thymidine labelling index. The preliminary results presented here show that higher TLI is associated with lower cytosol levels of both TPA and TPS. TPA and TPS in the cytosol were significantly associated. These findings are in agreement with the previously demonstrated association between high TPA cytosol levels and better prognosis in breast cancer. Further studies are ongoing in order to: 1. confirm these findings in a larger patient series; 2. investigate any possible prognostic indication provided by TPS; 3. evaluate any possible biological meaning of the negative association between TPA/TPS and TLI in the cytosol of breast cancer.
血清肿瘤标志物组织多肽抗原（TPA）以及最近发现的组织特异性多肽抗原（TPS）已被报道为肿瘤增殖率的指标。在本研究中，我们将这两种标志物的胞浆水平与使用3H-胸腺嘧啶核苷标记指数测量的肿瘤增殖活性进行了比较。此处呈现的初步结果表明，较高的标记指数与TPA和TPS较低的胞浆水平相关。胞浆中的TPA和TPS显著相关。这些发现与先前证明的乳腺癌中高TPA胞浆水平与较好预后之间的关联一致。进一步的研究正在进行，目的是：1. 在更大的患者系列中证实这些发现；2. 研究TPS提供的任何可能的预后指标；3. 评估乳腺癌胞浆中TPA/TPS与标记指数之间负相关的任何可能生物学意义。
