α1-酸性糖蛋白对肿瘤坏死因子诱导的致死性的保护作用。
Protection by alpha 1-acid glycoprotein against tumor necrosis factor-induced lethality.
作者信息
Libert C, Brouckaert P, Fiers W
机构信息
Laboratory of Molecular Biology, University of Gent, Belgium.
出版信息
J Exp Med. 1994 Oct 1;180(4):1571-5. doi: 10.1084/jem.180.4.1571.
Abstract
We here report that alpha 1-acid glycoprotein, a typical acute phase protein, protects mice from lethal shock induced by tumor necrosis factor (TNF) or endotoxin. The protection is observed both in normal and in galactosamine-sensitized mice. Optimal desensitization requires at least 3 mg alpha 1-acid glycoprotein administered 2 h before the lethal challenge. Under these conditions, complete inhibition of all TNF-induced metabolic changes was observed: fall in body temperature, release of liver transaminases, enhanced clotting time, and mortality. The known platelet aggregation-inhibitory activity of alpha 1-acid glycoprotein provides a possible explanation for this protective capacity.
摘要
我们在此报告，α1-酸性糖蛋白作为一种典型的急性期蛋白，可保护小鼠免受肿瘤坏死因子（TNF）或内毒素诱导的致死性休克。在正常小鼠和半乳糖胺致敏小鼠中均观察到这种保护作用。最佳脱敏需要在致死性攻击前2小时给予至少3毫克α1-酸性糖蛋白。在这些条件下，观察到所有TNF诱导的代谢变化完全受到抑制：体温下降、肝转氨酶释放、凝血时间延长和死亡率。α1-酸性糖蛋白已知的血小板聚集抑制活性为这种保护能力提供了一种可能的解释。
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