Sample J, Kieff E F, Kieff E D
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115.
J Gen Virol. 1994 Oct;75 ( Pt 10):2741-6. doi: 10.1099/0022-1317-75-10-2741.
Although variation in the gene encoding the Epstein-Barr virus (EBV) nuclear protein 2 accounts for much of the difference in the transforming activities of the two EBV strain types, divergence in the principal lymphocyte growth-altering gene, LMP-1, has not been previously evaluated. We have now determined the nucleotide sequence of the LMP-1 gene of a type 2 isolate of EBV, AG876. Surprisingly, the AG876 LMP-1 protein is 93% identical to the prototype type 1 EBV strain B95-8, and this is well within the range of variability previously noted among type 1 EBV LMP-1 genes.
尽管编码爱泼斯坦-巴尔病毒（EBV）核蛋白2的基因变异在两种EBV毒株类型的转化活性差异中占了很大比例，但主要的淋巴细胞生长改变基因LMP-1的差异此前尚未得到评估。我们现已确定了EBV 2型分离株AG876的LMP-1基因的核苷酸序列。令人惊讶的是，AG876 LMP-1蛋白与1型EBV原型毒株B95-8有93%的同一性，这完全在先前1型EBV LMP-1基因之间所观察到的变异范围内。
