Giunchedi P, Conti B, Maggi L, Conte U
Department of Pharmaceutical Chemistry, University of Pavia, Italy.
J Microencapsul. 1994 Jul-Aug;11(4):381-93. doi: 10.3109/02652049409034256.
Ketoprofen-loaded microspheres made with a polymeric blend were prepared by a spray-drying technique. Organic solutions of two polymers, cellulose acetate butyrate (CAB) and poly(epsilon-caprolactone) (PCL), in different weight ratios, and of ketoprofen (Ket) were prepared and sprayed, in different experimental conditions, achieving drug-loaded microspheres. The obtained spray-dried microspheres were characterized in terms of yield of production, shape, size, surface properties and drug content, and their in vitro drug release behaviours were determined at different pH values.
采用喷雾干燥技术制备了由聚合物共混物制成的载酮洛芬微球。制备了两种聚合物醋酸丁酸纤维素（CAB）和聚己内酯（PCL）不同重量比的酮洛芬（Ket）有机溶液，并在不同实验条件下进行喷雾，得到载药微球。对所得喷雾干燥微球的产量、形状、尺寸、表面性质和药物含量进行了表征，并测定了它们在不同pH值下的体外药物释放行为。
