Giunchedi P, Torre M L, Maggi L, Conti B, Conte U
Department of Pharmaceutical Chemistry, University of Pavia, Italy.
J Microencapsul. 1996 Jan-Feb;13(1):89-98. doi: 10.3109/02652049609006805.
Ketoprofen (Ket), a non-steroidal anti-inflammatory drug, has been incorporated into polymeric micromatrices (microspheres) prepared by a spray drying process and made of cellulose acetate trimellitate (CAT)/ethylcellulose (EC) blends. Drug loaded microspheres were obtained by spray-drying organic solutions of the two polymers and the drug. Characterization of the microparticles (morphology, particle size distribution, drug content, yield of production, surface properties, solvent residues) was carried out and in-vitro release behaviour measured. The release rate of the drug diminished as the proportion of EC was raised.
酮洛芬（Ket）是一种非甾体抗炎药，已被载入通过喷雾干燥工艺制备的、由三醋酸纤维素（CAT）/乙基纤维素（EC）共混物制成的聚合物微基质（微球）中。载药微球是通过对两种聚合物和药物的有机溶液进行喷雾干燥而获得的。对微粒进行了表征（形态、粒度分布、药物含量、产率、表面性质、溶剂残留）并测定了体外释放行为。随着EC比例的提高，药物的释放速率降低。
