Fishman S M, Carr D B, Beckett A, Rosenbaum J F
Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston.
J Psychiatr Res. 1994 Mar-Apr;28(2):165-70. doi: 10.1016/0022-3956(94)90027-2.
We tested the ventilatory and anxiety response to hypercapneic (CO2) challenge in women with panic disorder as well as in normal women in the premenstrual phase and mid-points of their menstrual cycles. Panic disorder patients were challenged on two occasions, each time while in the premenstrual phase of the menstrual cycle, receiving an open trial of alprazolam through the intervening 8 weeks between tests. This study confirms previous reports indicating increased sensitivity to CO2 in patients with panic disorder and that this sensitivity can be attenuated by treatment. We found a significant decrease in the ventilatory response of panic disorder patients comparing pre- and post-therapy. We also observed that normal females, while in the premenstrual phase of their menstrual cycle, have a heightened anxiety response to CO2 challenge.
我们测试了恐慌症女性以及处于月经周期经前期和中期的正常女性对高碳酸血症（二氧化碳）激发试验的通气和焦虑反应。恐慌症患者接受了两次激发试验，每次均处于月经周期的经前期，在两次试验间隔的8周期间接受了阿普唑仑的开放试验。这项研究证实了先前的报告，即恐慌症患者对二氧化碳的敏感性增加，且这种敏感性可通过治疗减弱。我们发现，与治疗前相比，恐慌症患者治疗后的通气反应显著降低。我们还观察到，正常女性在月经周期的经前期对二氧化碳激发试验的焦虑反应增强。
