焦虑敏感、月经周期与惊恐障碍：一种假定的神经内分泌和心理交互作用。
Anxiety sensitivity, the menstrual cycle, and panic disorder: a putative neuroendocrine and psychological interaction.
机构信息
Department of Psychology, University of Vermont, John Dewey Hall, 2 Colchester Ave., Burlington, VT 05405, USA.
出版信息
Clin Psychol Rev. 2011 Nov;31(7):1183-91. doi: 10.1016/j.cpr.2011.07.006. Epub 2011 Jul 26.
Abstract
The 2:1 female-to-male sex difference in the prevalence of panic disorder (PD) suggests that there is a sex-specific vulnerability involved in the etiology and/or maintenance of this disorder. The purpose of this paper is to present a new conceptual model, which emphasizes the interaction between a cognitive vulnerability for PD, anxiety sensitivity, and the effects of progesterone and its metabolite, allopregnanolone, on behavioral and physiological responses to stress during the premenstrual phase. This interaction is proposed to be a potential sex-specific pathway that may initiate and/or maintain panic and anxiety symptoms in women. This review paper presents preliminary evidence from both the human and animal literatures to support this new model. Specific topics reviewed include: psychopathology related to the menstrual cycle, anxiety sensitivity and its relationship to the menstrual cycle, PMS, and PMDD, anxiety-modulating effects of progesterone and its neuroactive metabolite, allopregnanolone, and how results from the neuroendocrine literature relate to psychopathology or symptoms associated with the menstrual cycle.
摘要
惊恐障碍（PD）的患病率存在 2:1 的男女性别差异，这表明在这种疾病的病因和/或维持中存在特定于性别的脆弱性。本文的目的是提出一个新的概念模型，该模型强调了对 PD 的认知脆弱性、焦虑敏感性以及孕激素及其代谢物别孕烯醇酮对经前期应激的行为和生理反应的影响之间的相互作用。这种相互作用被认为是一种潜在的特定于性别的途径，可能会引发和/或维持女性的恐慌和焦虑症状。这篇综述文章从人类和动物文献中提供了初步证据来支持这个新模型。综述的具体主题包括：与月经周期相关的精神病理学、焦虑敏感性及其与月经周期的关系、经前综合征（PMS）和经前烦躁障碍（PMDD）、孕激素及其神经活性代谢物别孕烯醇酮的焦虑调节作用，以及神经内分泌文献中的结果如何与与月经周期相关的精神病理学或症状相关。
相似文献
1
Anxiety sensitivity, the menstrual cycle, and panic disorder: a putative neuroendocrine and psychological interaction.焦虑敏感、月经周期与惊恐障碍：一种假定的神经内分泌和心理交互作用。
Clin Psychol Rev. 2011 Nov;31(7):1183-91. doi: 10.1016/j.cpr.2011.07.006. Epub 2011 Jul 26.
2
The role of menstrual cycle phase and anxiety sensitivity in catastrophic misinterpretation of physical symptoms during a CO(2) challenge.月经周期阶段和焦虑敏感性在 CO(2) 挑战期间对身体症状的灾难性误解中的作用。
Arch Womens Ment Health. 2012 Dec;15(6):413-22. doi: 10.1007/s00737-012-0302-2. Epub 2012 Aug 25.
3
The influence of the menstrual cycle on reactivity to a CO challenge among women with and without premenstrual symptoms.月经周期对有经前症状和无经前症状女性一氧化碳激发反应性的影响。
Cogn Behav Ther. 2017 Apr;46(3):239-249. doi: 10.1080/16506073.2016.1236286. Epub 2016 Sep 30.
4
The role of perceived control over anxiety in prospective symptom reports across the menstrual cycle.在整个月经周期中，感知到的对焦虑的控制在预期症状报告中的作用。
Arch Womens Ment Health. 2015 Apr;18(2):239-246. doi: 10.1007/s00737-014-0456-1. Epub 2014 Oct 1.
5
Women with premenstrual dysphoric disorder have altered sensitivity to allopregnanolone over the menstrual cycle compared to controls-a pilot study.与对照组相比，经前烦躁障碍女性在月经周期中对别孕烯醇酮的敏感性有所改变——一项初步研究。
Psychopharmacology (Berl). 2016 Jun;233(11):2109-2117. doi: 10.1007/s00213-016-4258-1. Epub 2016 Mar 10.
6
The role of anxiety sensitivity in the experience of menstrual-related symptoms reported via daily diary.焦虑敏感性在通过日常日记报告的月经相关症状体验中的作用。
Psychiatry Res. 2013 Dec 15;210(2):564-9. doi: 10.1016/j.psychres.2013.07.016. Epub 2013 Jul 31.
7
Physiological and psychological reactivity in women with asthma: the effects of anxiety and menstrual cycle phase.哮喘女性的生理和心理反应性：焦虑和月经周期阶段的影响。
Behav Res Ther. 2002 Jan;40(1):3-17. doi: 10.1016/s0005-7967(00)00110-8.
8
Psychophysiological, somatic, and affective changes across the menstrual cycle in women with panic disorder.恐慌症女性在月经周期中的心理生理、躯体和情感变化。
J Consult Clin Psychol. 2000 Jun;68(3):425-31. doi: 10.1037//0022-006x.68.3.425.
9
Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study.健康女性及经前烦躁障碍女性月经周期中皮质γ-氨基丁酸水平：一项质子磁共振波谱研究
Arch Gen Psychiatry. 2002 Sep;59(9):851-8. doi: 10.1001/archpsyc.59.9.851.
10
GABA receptors, progesterone and premenstrual dysphoric disorder.γ-氨基丁酸受体、孕酮与经前烦躁障碍
Arch Womens Ment Health. 2003 Feb;6(1):23-41. doi: 10.1007/s00737-002-0147-1.
引用本文的文献
1
Physical and Mental Recovery for Female Footballers: Considerations and Approaches for Better Practice.女足运动员的身心恢复：更好实践的考量与方法
Sports Med. 2025 Aug 25. doi: 10.1007/s40279-025-02246-x.
2
Understanding premenstrual dysphoric disorder from a psychosomatic and a sensory perspective.从身心和感官角度理解经前烦躁障碍
Front Glob Womens Health. 2025 Jul 21;6:1595083. doi: 10.3389/fgwh.2025.1595083. eCollection 2025.
3
Difficulties with emotion regulation amplify perimenstrual emotional distress and cigarette craving.情绪调节困难会加剧经前情绪困扰和对香烟的渴望。
Psychol Addict Behav. 2025 May;39(3):311-319. doi: 10.1037/adb0001065. Epub 2025 Apr 7.
4
Factors Associated with Mental Illness in a Primary Healthcare Setting in the Kingdom of Saudi Arabia: A Case-Control Study.沙特阿拉伯王国初级医疗保健环境中与精神疾病相关的因素：一项病例对照研究。
Healthcare (Basel). 2024 Jun 28;12(13):1298. doi: 10.3390/healthcare12131298.
5
The Impacts of Sex Differences and Sex Hormones on Fear Extinction.性别差异和性激素对恐惧消退的影响。
Curr Top Behav Neurosci. 2023;64:105-132. doi: 10.1007/7854_2023_426.
6
Estrogens, age, and, neonatal stress: panic disorders and novel views on the contribution of non-medullary structures to respiratory control and CO responses.雌激素、年龄与新生儿应激：惊恐障碍以及关于非髓质结构对呼吸控制和二氧化碳反应贡献的新观点。
Front Physiol. 2023 May 17;14:1183933. doi: 10.3389/fphys.2023.1183933. eCollection 2023.
7
Effects of acute estradiol and progesterone on perimenstrual exacerbation of suicidal ideation and related symptoms: a crossover randomized controlled trial.雌二醇和孕酮对经前期自杀意念及相关症状恶化的影响：一项交叉随机对照试验。
Transl Psychiatry. 2022 Dec 30;12(1):528. doi: 10.1038/s41398-022-02294-1.
8
Predicting Chronic Stress among Healthy Females Using Daily-Life Physiological and Lifestyle Features from Wearable Sensors.利用可穿戴传感器的日常生活生理和生活方式特征预测健康女性的慢性压力。
Chronic Stress (Thousand Oaks). 2022 Jul 25;6:24705470221100987. doi: 10.1177/24705470221100987. eCollection 2022 Jan-Dec.
9
'That time of the month' … for the biggest event of your career! Perception of menstrual cycle on performance of Australian athletes training for the 2020 Olympic and Paralympic Games.“每月的那个时候”……关乎你职业生涯中最重要的赛事！澳大利亚参加2020年奥运会和残奥会训练的运动员对月经周期对其表现的认知 。
BMJ Open Sport Exerc Med. 2022 Apr 12;8(2):e001300. doi: 10.1136/bmjsem-2021-001300. eCollection 2022.
10
Psychiatric Symptoms Across the Menstrual Cycle in Adult Women: A Comprehensive Review.成年女性月经周期中的精神症状：一项综合综述。
Harv Rev Psychiatry. 2022;30(2):100-117. doi: 10.1097/HRP.0000000000000329.
本文引用的文献
1
The effects of female reproductive hormones in generalized social anxiety disorder.女性生殖激素对广泛性社交焦虑障碍的影响。
Int J Psychiatry Med. 2009;39(3):283-95. doi: 10.2190/PM.39.3.e.
2
Anxiety sensitivity and the anxiety disorders: a meta-analytic review and synthesis.焦虑敏感与焦虑障碍：一项元分析综述与综合。
Psychol Bull. 2009 Nov;135(6):974-99. doi: 10.1037/a0017428.
3
Brave men and timid women? A review of the gender differences in fear and anxiety.勇敢的男性与胆小的女性？关于恐惧和焦虑中性别差异的综述。
Clin Psychol Rev. 2009 Aug;29(6):496-505. doi: 10.1016/j.cpr.2009.05.003. Epub 2009 Jun 7.
4
Patterns of mood changes throughout the reproductive cycle in healthy women without premenstrual dysphoric disorders.无经前烦躁障碍的健康女性在整个生殖周期中的情绪变化模式。
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Dec 12;32(8):1782-8. doi: 10.1016/j.pnpbp.2008.07.016. Epub 2008 Jul 30.
5
Patients with premenstrual dysphoric disorder have increased startle response across both cycle phases and lower levels of prepulse inhibition during the late luteal phase of the menstrual cycle.经前烦躁障碍患者在月经周期的两个阶段惊吓反应均增强，且在月经周期黄体晚期的前脉冲抑制水平较低。
Neuropsychopharmacology. 2008 Aug;33(9):2283-90. doi: 10.1038/sj.npp.1301599. Epub 2007 Oct 17.
6
Differences in symptom scores and health outcomes in premenstrual syndrome.经前综合征的症状评分与健康结局差异。
J Womens Health (Larchmt). 2007 Oct;16(8):1139-44. doi: 10.1089/jwh.2006.0230.
7
Robust dimensions of anxiety sensitivity: development and initial validation of the Anxiety Sensitivity Index-3.焦虑敏感性的稳健维度：焦虑敏感性指数-3的编制与初步验证
Psychol Assess. 2007 Jun;19(2):176-88. doi: 10.1037/1040-3590.19.2.176.
8
Neurosteroid regulation of GABA(A) receptors: Focus on the alpha4 and delta subunits.神经甾体对γ-氨基丁酸A型（GABA(A)）受体的调节：聚焦于α4和δ亚基
Pharmacol Ther. 2007 Oct;116(1):58-76. doi: 10.1016/j.pharmthera.2007.03.008. Epub 2007 Apr 21.
9
Taxometric and factor analytic models of anxiety sensitivity: integrating approaches to latent structural research.焦虑敏感性的税基测量和因素分析模型：整合潜在结构研究方法
Psychol Assess. 2007 Mar;19(1):74-87. doi: 10.1037/1040-3590.19.1.74.
10
Anxiety sensitivity and panic attacks: a 1-year longitudinal study.焦虑敏感性与惊恐发作：一项为期1年的纵向研究。
Behav Modif. 2007 Mar;31(2):145-61. doi: 10.1177/0145445506296969.
Zotero 插件