Gao Y, Short R V
Department of Physiology, Monash University, Melbourne, Victoria, Australia.
J Reprod Fertil. 1994 Jul;101(2):483-7. doi: 10.1530/jrf.0.1010483.
Paraffin blocks containing either no steroid, 150 mg RU486 kg-1, 500 mg methyl testosterone kg-1 or 1500 mg methyl testosterone kg-1 were fed to wild mice (Mus musculus) in addition to the standard laboratory diet in four large (3 m x 3 m) outdoor pens for six months over the summer. The RU486 bait was provided for only 3 days every 18 or 21 days, whereas the methyl testosterone bait was available continuously. From a foundation stock of 20 mice (nine male, eleven female) in each pen, the population had increased to 253 (control), 72 (RU486), 249 (low methyl testosterone concentration) and 103 (high methyl testosterone concentration) at the end of six months, when 17%, 4%, 32% and 13% of the mature females were pregnant in the respective treatment groups. There was little evidence of an increase in the incidence of injuries in the androgen-treated animals. Daily estimation of water consumption in the pens proved to be a good non-invasive way of monitoring population growth during the course of the experiment. Intermittent feeding with a low concentration of RU486 appeared to be much more successful in inhibiting reproduction than continuous feeding with a high concentration of methyl testosterone, and it therefore offers a new method for controlling feral mouse populations.
除了标准实验室饮食外，在夏季的六个月里，将含有不同成分的石蜡块投喂给户外四个大型（3米×3米）围栏中的野生小鼠（小家鼠）。这些石蜡块分别不含类固醇、含有150毫克RU486/千克、500毫克甲基睾酮/千克或1500毫克甲基睾酮/千克。RU486诱饵每18或21天只提供3天，而甲基睾酮诱饵则持续供应。每个围栏最初有20只小鼠（9只雄性，11只雌性），六个月结束时，数量分别增加到253只（对照组）、72只（RU486组）、249只（低甲基睾酮浓度组）和103只（高甲基睾酮浓度组），此时各治疗组中17%、4%、32%和13%的成年雌性小鼠怀孕。几乎没有证据表明雄激素处理组动物的受伤发生率增加。在实验过程中，每天估算围栏内的耗水量被证明是监测种群增长的一种很好的非侵入性方法。间歇性投喂低浓度的RU486在抑制繁殖方面似乎比持续投喂高浓度的甲基睾酮更成功，因此它为控制野生小鼠种群提供了一种新方法。
