基于结构的HIV蛋白酶抑制剂设计：4-羟基香豆素和4-羟基-2-吡喃酮作为非肽类抑制剂 - Suppr

Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors.

作者信息

Thaisrivongs S, Tomich P K, Watenpaugh K D, Chong K T, Howe W J, Yang C P, Strohbach J W, Turner S R, McGrath J P, Bohanon M J

机构信息

Medicinal Chemistry Research, Upjohn Laboratories, Kalamazoo, Michigan 49001.

出版信息

J Med Chem. 1994 Sep 30;37(20):3200-4. doi: 10.1021/jm00046a002.

DOI:10.1021/jm00046a002

PMID:7932546

Abstract

摘要

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Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors.

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Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors.

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