Schäberle Till F
Institute for Pharmaceutical Biology, University of Bonn, Nußallee 6, 53115 Bonn, Germany.
Beilstein J Org Chem. 2016 Mar 24;12:571-88. doi: 10.3762/bjoc.12.56. eCollection 2016.
The α-pyrone moiety is a structural feature found in a huge variety of biologically active metabolites. In recent times new insights into additional biosynthetic mechanisms, yielding in such six-membered unsaturated ester ring residues have been obtained. The purpose of this mini-review is to give a brief overview of α-pyrones and the mechanisms forming the basis of their natural synthesis. Especially the chain interconnecting enzymes, showing homology to ketosynthases which catalyze Claisen-like condensation reactions, will be presented.
α-吡喃酮部分是在大量生物活性代谢产物中发现的一种结构特征。近年来，人们对产生这种六元不饱和酯环残基的额外生物合成机制有了新的认识。本综述的目的是简要概述α-吡喃酮及其天然合成的基础机制。特别是将介绍与催化类似克莱森缩合反应的酮合成酶具有同源性的链连接酶。
