Igari J, Oguri T, Higuchi T
Department of Clinical Pathology, Juntendo University School of Medicine.
Jpn J Antibiot. 1994 Aug;47(8):1013-29.
The Antibacterial activity of minocycline (MINO) and that of cefuzonam (CZON) were assessed with clinical isolates of 19 species, and compared with that of other antibiotics. MINO was highly active against methicilli-sensitive Staphylococcus aureus (MSSA), Neisseria gonorrhoeae, Moraxella (Branhamella) catarrhalis, Haemophilus influenzae, Helicobacter pylori, Flavobacterium meningosepticum, Acinetobacter calcoaceticus, Peptostreptococcus spp. and Propionibacterium acnes, but not as effective against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas cepacia and Alcaligenes xylosoxidans. CZON was highly active against MSSA, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae, N. Gonorrhoeae, M(B). catarrhalis, H. influenzae, H. pylori, P. mirabilis, Peptostreptococcus spp. and P. acnes, but not effective against MRSA. It was minimally active against Gram-negative rods (E. coli, K. pneumoniae, etc.) and bacteria that do not ferment glucose.
用19种临床分离菌株评估了米诺环素（MINO）和头孢唑南（CZON）的抗菌活性，并与其他抗生素进行了比较。米诺环素对甲氧西林敏感金黄色葡萄球菌（MSSA）、淋病奈瑟菌、卡他莫拉菌（布兰汉菌属）、流感嗜血杆菌、幽门螺杆菌、脑膜败血黄杆菌、醋酸钙不动杆菌、消化链球菌属和痤疮丙酸杆菌具有高活性，但对耐甲氧西林金黄色葡萄球菌（MRSA）、大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌、洋葱伯克霍尔德菌和木糖氧化产碱杆菌效果不佳。头孢唑南对MSSA、化脓性链球菌、无乳链球菌、肺炎链球菌、淋病奈瑟菌、卡他莫拉菌、流感嗜血杆菌、幽门螺杆菌、奇异变形杆菌、消化链球菌属和痤疮丙酸杆菌具有高活性，但对MRSA无效。它对革兰氏阴性杆菌（大肠埃希菌、肺炎克雷伯菌等）和不发酵葡萄糖的细菌活性最低。
