[Susceptibilities of glucose non-fermentative gram-negative bacilli to antibiotics].

Glucose non-fermentative Gram-negative bacilli are important nosocomial pathogens. This study concerned with susceptibilities to antibacterial agents of strains of Glucose non-fermentative Gram-negative bacilli that were isolated from cultures of clinical materials at 123 hospital laboratories throughout Japan from September to December of 1991. The tests for susceptibilities were performed according to the disk dilution method recommended by NCCLS. The following bacteria were tested: Pseudomonas aeruginosa, Pseudomonas cepacia, Acinetobacter calcoaceticus, Alcaligenes spp., Alcaligenes xylosoxidans, Flavobacterium spp. and Xanthomonas maltophilia. The antibacterial agents tested were as follows: piperacillin (PIPC), ceftazidime (CAZ), aztreonam (AZT), imipenem (IPM), minocycline (MINO), gentamicin, amikacin (AMK) and ofloxacin (OFLX). 1. Eighty percent of the strains of P. aeruginosa and P. cepacia were sensitive to CAZ. More than ninety percent of the strains of A. calcoaceticus were sensitive to IPM, MINO, OFLX. To PIPC and IPM, about eighty percent of the strains of Alcaligenes spp. and A. xylosoxidans were sensitive. The strains of Flavobacterium spp. and X. maltophilia showed high sensitivities to MINO. 2. Annual changes in antimicrobial susceptibility patterns over 4 years (1988-1991) show that there has been a gradual increase in sensitive strains of P. aeruginosa to PIPC, CAZ and AMK. Sensitive strains of P. cepacia to AZT, IPM and MINO, and A. calcoaceticus to CAZ and MINO also have gradually increased. No yearly changes were observed in high sensitivity to MINO of the strains of Flavobacterium spp. and X. maltophilia.