Kouda M, Fukuhara J, Takeuchi M, Ohgawara M, Matsuzaki H, Tohi H, Furuhata N, Maruyama M, Sasaki K, Sawabe E, Ikeda A, Suzuki T, Satoh H, Takahashi I, Kimura F, Nomura H, Ono E
First Division of Clinical Laboratories, Tokyo Metropolitan Police Hospital.
Jpn J Antibiot. 1998 Jul;51(7):475-87.
MICs of piperacillin, sulbactam/cefoperazone, minocycline (MINO), gentamicin, amikacin, flomoxef, ceftazidime, cefozopran, cefsulodin and imipenem were determined, against 189 clinical isolated strains of glucose non-fermentative Gram-negative Rods (NFGNR; Acinetobacter baumannii (44), Alcaligenes faecalis (5), Alcaligenes xylosoxidans (25), Burkholderia cepacia (12), Chryseobacterium indologenes (23), Chryseobacterium meningosepticum (9), Pseudomonas fluorescens (8), Pseudomonas putida (12), Stenotrophomonas maltophilia (51). Most species of these NFGNR show resistance to many antibiotics tested. Among the antibiotics used in this study, the only antibiotic effective against all species of NFGNR tested is MINO. The spectrums of antibacterial activities of various antibiotics determined by MICs may be useful in preliminary test for identification of these NFGNR.
测定了哌拉西林、舒巴坦/头孢哌酮、米诺环素（MINO）、庆大霉素、阿米卡星、氟氧头孢、头孢他啶、头孢唑兰、头孢磺啶和亚胺培南对189株临床分离的葡萄糖非发酵革兰氏阴性杆菌（NFGNR；鲍曼不动杆菌（44株）、粪产碱杆菌（5株）、木糖氧化产碱杆菌（25株）、洋葱伯克霍尔德菌（12株）、产吲哚金黄杆菌（23株）、脑膜炎败血金黄杆菌（9株）、荧光假单胞菌（8株）、恶臭假单胞菌（12株）、嗜麦芽窄食单胞菌（51株））的最低抑菌浓度（MIC）。这些NFGNR的大多数菌种对所测试的许多抗生素都有耐药性。在本研究中使用的抗生素中，唯一对所有测试的NFGNR菌种有效的抗生素是米诺环素。通过MIC测定的各种抗生素的抗菌活性谱可能有助于对这些NFGNR进行初步鉴定测试。
