Nakahashi E, Kuribayashi N, Tsuji N, Kawaguchi T, Hata H, Matsuzaki H, Shimizu K, Takatsuki K
Second Department of Internal Medicine, Kumamoto University School of Medicine.
Rinsho Ketsueki. 1994 Aug;35(8):756-60.
A 23-year-old male patient with plasma cell leukemia showed characteristic clinical features: accelerating heart failure and consciousness disturbance accompanied with an increase of plasma cells in peripheral blood. Evaluation of cardiac function revealed a hyperdynamic cardiac state with low somatic vascular resistance, indicating high-output cardiac failure. However no disorders causing high-output cardiac failure were found. Consciousness disturbance and hyperammonemia with serum amino acid abnormality of unknown origin were also demonstrated. After intensive combined chemotherapy (MVD + VAD), high-output cardiac failure and hyperammonemia improved with disappearance of plasma cells, suggesting that these symptoms were closely related with progression of plasma cell leukemia.
一名患有浆细胞白血病的23岁男性患者表现出特征性临床特征：心力衰竭加速和意识障碍，同时外周血中浆细胞增多。心脏功能评估显示心脏处于高动力状态，体循环血管阻力降低，提示高输出量心力衰竭。然而，未发现导致高输出量心力衰竭的疾病。还出现了意识障碍和不明原因的高氨血症伴血清氨基酸异常。经过强化联合化疗（MVD + VAD），随着浆细胞消失，高输出量心力衰竭和高氨血症得到改善，表明这些症状与浆细胞白血病的进展密切相关。
