Nasu K, Matsubayashi H, Maeda Y, Matsuura R, Suzuki A, Kasakura S
Department of Clinical Pathology, Kobe City General Hospital.
Rinsho Ketsueki. 1994 Aug;35(8):774-9.
This report is of a patient with adult T cell leukemia (ATL) in the smoldering stage showing expression an aberrant phenotype of CD3-, CD4+ and CD8-. A 71-year-old woman was admitted to our hospital in December 1992, because of skin eruption and persistent low grade fever. Laboratory examination showed a leukocyte count of 7,000/microliter with 29% abnormal lymphocytes. The diagnosis of ATL was made by the detection of serum anti-HTLV-I antibody and the monoclonal integration of HTLV-I proviral DNA in abnormal lymphocytes. ATL cells at diagnosis were CD3+, CD4+ and CD8+. However, one month later ATL cells lacked CD3 and CD8. Three color analysis showed that most of the CD25+ cells were CD3- and CD4+.
本报告介绍了一名处于冒烟期的成人T细胞白血病（ATL）患者，其表现出CD3 -、CD4 +和CD8 -的异常表型。一名71岁女性于1992年12月因皮肤疹和持续低热入院。实验室检查显示白细胞计数为7000/微升，其中29%为异常淋巴细胞。通过检测血清抗HTLV - I抗体以及HTLV - I前病毒DNA在异常淋巴细胞中的单克隆整合确诊为ATL。诊断时ATL细胞为CD3 +、CD4 +和CD8 +。然而，一个月后ATL细胞缺乏CD3和CD8。三色分析显示，大多数CD25 +细胞为CD3 -和CD4 +。
