Iwahashi M, Nakahara K, Takeshita T, Shimotakahara S, Uozumi K, Hanada S
Department of Internal Medicine, Minami Kyushu Chuo National Hospital.
Rinsho Ketsueki. 1991 Feb;32(2):142-6.
A 51-year-old woman was admitted to our hospital complaining of lymphadenopathy in June, 1987. Lymph node biopsy revealed diffuse lymphoma, mixed cell type according to the LSG classification. On hematological examinations, leukocyte has counted 12,400/microliters, of which 15% abnormal lymphocytes containing human T cell lymphotropic virus type-1 (HTLV-1) proviral DNA into the cellular DNA. She was diagnosed as adult T-cell leukemia (ATL). The abnormal lymphocytes in the peripheral blood expressed CD4 but lymph node cells expressed CD8. Thirty months after initial diagnosis, abnormal lymphocytes began to increased and reached 30,500/microliters. Surface phenotype of abnormal lymphocytes changed CD3+ CD4+ CD8- OKla1+ to CD3- CD4- CD8- OKla1-. This change is considered to show the surface phenotypic diversity in ATL cells.
一名51岁女性于1987年6月因淋巴结病入住我院。淋巴结活检显示为弥漫性淋巴瘤，根据LSG分类为混合细胞型。血液学检查显示，白细胞计数为12400/微升，其中15%的异常淋巴细胞含有1型人类嗜T细胞病毒（HTLV-1）前病毒DNA并整合到细胞DNA中。她被诊断为成人T细胞白血病（ATL）。外周血中的异常淋巴细胞表达CD4，而淋巴结细胞表达CD8。初诊30个月后，异常淋巴细胞开始增多，达到30500/微升。异常淋巴细胞的表面表型从CD3+CD4+CD8-OKla1+变为CD3-CD4-CD8-OKla1-。这种变化被认为显示了ATL细胞的表面表型多样性。
