以麻木性下巴综合征为首发表现的多发性骨髓瘤

[Multiple myeloma with numb chin syndrome as the initial manifestation].

作者信息

Shiroshita N, Kurosawa M, Okabe M, Chuuma M, Yamamoto Y, Sakurada K, Miyazaki T

机构信息

Third Department of Internal Medicine, Hokkaido University School of Medicine.

出版信息

Rinsho Ketsueki. 1994 Aug;35(8):792-7.

PMID:7933568

Abstract

The numb chin syndrome (NCS) is characterized by chin or lower lip numbness restricted to the distribution of the mental nerve (the distal trigeminal nerve). A case of multiple myeloma with polycythemia vera was diagnosed with NCS as the initial manifestation. A 73-year-old Japanese male was admitted to our hospital in April, 1993, because of paresthesia around the chin and lower lip. X-ray film showed multiple osteolytic lesions. According to serum and urine immunoelectrophoresis, lambda type Bence Jones protein was demonstrated. The bone marrow aspiration showed the normocellular marrow with 14.1% myeloma cells. He was diagnosed a suffering from multiple myeloma and was treated with melphalan and prednisolone. He is alive at present with resolution of NCS. We discussed pathogenesis, diagnosis, and treatment of NCS.

摘要

麻木性下巴综合征（NCS）的特征是下巴或下唇麻木，局限于颏神经（三叉神经远端）的分布区域。一例伴有真性红细胞增多症的多发性骨髓瘤患者以NCS作为首发表现被诊断出来。一名73岁的日本男性于1993年4月因下巴和下唇周围感觉异常入住我院。X线片显示多处溶骨性病变。根据血清和尿液免疫电泳，证实存在λ型本-周蛋白。骨髓穿刺显示骨髓细胞正常，骨髓瘤细胞占14.1%。他被诊断为患有多发性骨髓瘤，并接受了美法仑和泼尼松龙治疗。目前他仍然存活，NCS症状已消失。我们讨论了NCS的发病机制、诊断和治疗。