Amitani R, Kuze F
Department of Infection and Inflammation, Kyoto University.
Nihon Rinsho. 1994 Aug;52(8):2072-6.
Churg-Strauss syndrome (allergic granulomatous angiitis) was described by Churg, J. and Strauss, L. in 1951 and was classified as a definite form of systemic vasculitis which was separated from classical periarteritis nodosa and other forms of necrotising angiitis by Zeek, P.M. in 1953. This disease is characterized pathologically by granulomatous necrotizing vasculitis associated with infiltration of eosinophils in multiple organs, particularly the lungs. The characteristic clinical and laboratory findings of the disease, which are helpful for obtaining definitive diagnosis, include severe asthmatic attacks, the presence of multiple pulmonary infiltrates, skin lesions, marked peripheral eosinophilia, elevation of serum IgE. Patients with the disease also complain of nonspecific symptoms such as fever, general malaise, anorexia and weight loss. Steroid therapy is usually effective for the disease. A representative case of Churg-Strauss syndrome is also presented.
1951年，朱尔格（Churg, J.）和施特劳斯（Strauss, L.）描述了变应性肉芽肿性血管炎（Churg-Strauss综合征），1953年，齐克（Zeek, P.M.）将其归类为一种明确的系统性血管炎形式，它与经典结节性多动脉炎及其他坏死性血管炎形式相区分。该病的病理特征为肉芽肿性坏死性血管炎，并伴有多个器官（尤其是肺部）嗜酸性粒细胞浸润。有助于明确诊断的该病特征性临床和实验室检查结果包括严重哮喘发作、多发肺部浸润、皮肤病变、显著外周血嗜酸性粒细胞增多、血清IgE升高。该病患者还会主诉发热、全身不适、厌食和体重减轻等非特异性症状。类固醇疗法通常对该病有效。本文还展示了1例变应性肉芽肿性血管炎的典型病例。
