Tanimoto K
Health Service Center, University of Saitama.
Nihon Rinsho. 1994 Aug;52(8):2120-2.
Mixed connective tissue disease (MCTD) was proposed by Sharp and others in 1972. MCTD is a unique disease in which the presence of nuclear RNP antibody is characteristic and the patient shows partial symptoms of SLE, PSS and or PM/DM. Among them, Raynaud's phenomenon and sausage like finger or swollen hand are the most common symptoms. Although patients with MCTD generally respond to small amount of corticosteroid and the prognosis is not so bad, some patients with MCTD especially those with pulmonary hypertension show high mortality.
混合性结缔组织病（MCTD）由夏普等人于1972年提出。MCTD是一种独特的疾病，其特征是存在核RNP抗体，患者表现出系统性红斑狼疮（SLE）、系统性硬化症（PSS）和/或多发性肌炎/皮肌炎（PM/DM）的部分症状。其中，雷诺现象和腊肠样手指或手部肿胀是最常见的症状。虽然MCTD患者通常对少量皮质类固醇有反应，预后也不算太差，但一些MCTD患者，尤其是那些患有肺动脉高压的患者，死亡率很高。
