Shirakawa S, Tamaki N, Torizuka T, Fujita T, Yano S, Tsuchimochi S, Yonekura Y, Konishi J, Terai A
Department of Radiology, Kyoto University Faculty of Medicine.
Kaku Igaku. 1994 Aug;31(8):977-83.
The clinical value of a newly developed renography agent 99mTc-mercaptoacetylglycylglycylglycine (99mTc-MAG3) was assessed in comparison with 123I-orthoiodohippurate (123I-OIH). A clear perfusion images were obtained early after 99mTc-MAG3 administration due to physical advantages of the tracer. A close correlation was observed of Tmax and T1/2 values between 99mTc-MAG3 and 123I-OIH. However, T1/2 calculated by 99mTc-MAG3 was significantly longer than that by 123I-OIH. In addition, the effective renal plasma flow (ERPF) value calculated by the clearance rate of the tracer by Tauxe method (radioactivity in plasma at 43 minutes after tracer administration) was smaller than that by 123I-OIH. In conclusion, 99mTc-MAG3 is considered as a useful agent for renography.
将新开发的肾图剂99m锝-巯基乙酰甘氨酰甘氨酰甘氨酸（99mTc-MAG3）与123碘-邻碘马尿酸（123I-OIH）进行比较，评估其临床价值。由于该示踪剂的物理优势，在注射99mTc-MAG3后早期即可获得清晰的灌注图像。观察到99mTc-MAG3与123I-OIH的Tmax和T1/2值密切相关。然而，99mTc-MAG3计算的T1/2明显长于123I-OIH计算的T1/2。此外，通过Tauxe方法（注射示踪剂后43分钟时血浆中的放射性）由示踪剂清除率计算的有效肾血浆流量（ERPF）值低于123I-OIH计算的值。总之，99mTc-MAG3被认为是一种用于肾图检查的有用试剂。
