Sato M, Hirayama K, Ishikawa N, Takeda T, Wu J, Itai Y, Kobayashi M, Koyama A
Department of Radiology, Tsukuba University.
Kaku Igaku. 1994 Jan;31(1):75-84.
The renal scintigraphy and clearance of 99mTc-mercaptoacetyltriglycine (MAG3) and 123I-ortho-iodohippuric acid (OIH) were compared in 12 patients with impaired renal function. The patients were first studied with MAG3 and then reinvestigated with OIH two days later. The MAG3 renal scintigraphy gave better quality and functional information in comparison with OIH. The MAG3 and OIH renogram showed identical relative kidney uptake and Tmax, but T1/2 of MAG3 was longer (p < 0.001). The plasma clearance of MAG3 was lower than that of OIH, but they correlated significantly (r = 0.87, p < 0.005). Also, the plasma clearances of MAG3 and para-aminohippuric acid (calculated by the standard clearance technique) showed good correlation (r = 0.77, p < 0.05). The urinary excretion during the first 60 min after injection was the same for the two radiopharmaceuticals. We conclude that 99mTc-MAG3 is a suitable alternative to 123I-OIH in renal scintigraphy.
对12例肾功能受损患者的肾脏闪烁显像以及99m锝-巯基乙酰三甘氨酸（MAG3）和123碘-邻碘马尿酸（OIH）的清除情况进行了比较。患者首先接受MAG3检查，两天后再用OIH重新检查。与OIH相比，MAG3肾脏闪烁显像能提供质量更好的功能信息。MAG3和OIH肾图显示肾脏相对摄取和Tmax相同，但MAG3的T1/2更长（p<0.001）。MAG3的血浆清除率低于OIH，但二者显著相关（r=0.87，p<0.005）。此外，MAG3和对氨基马尿酸（通过标准清除技术计算）的血浆清除率也显示出良好的相关性（r=0.77，p<0.05）。两种放射性药物注射后最初60分钟内的尿排泄情况相同。我们得出结论，在肾脏闪烁显像中，99mTc-MAG3是123I-OIH的合适替代物。
