Miyakawa T, Katsuragi S, Yamashita K, Ohuchi K
Department of Neuropsychiatry, Kumamoto University Medical School, Japan.
Jpn J Psychiatry Neurol. 1994 Mar;48(1):43-7. doi: 10.1111/j.1440-1819.1994.tb02995.x.
There are two types of neurofibrillary tangles, namely, a twisted tubule and a straight or uniform tubule in the same cell in the brain with Alzheimer's disease. However, in some parts of the same fibril, both the twisted and straight tubules clearly could be seen as a continuation of each other. This finding suggests that both of the tubules have a deep relation to each other, especially at the molecular level. This might also suggest the possibility of both tubules which mutually transform into each other.
在患有阿尔茨海默病的大脑中，存在两种类型的神经原纤维缠结，即在同一个细胞内的扭曲小管和直的或均匀的小管。然而，在同一纤维的某些部分，可以清楚地看到扭曲小管和直小管是彼此的延续。这一发现表明，这两种小管相互之间存在着密切关系，尤其是在分子水平上。这也可能暗示了两种小管相互转化的可能性。
