Cras P, Smith M A, Richey P L, Siedlak S L, Mulvihill P, Perry G
Division of Neuropathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Acta Neuropathol. 1995;89(4):291-5. doi: 10.1007/BF00309621.
In this report we quantitatively assess the numbers of intracellular and extracellular neurofibrillary tangles (NFT) in the brains of a series of individuals with Alzheimer's disease and of controls and correlate these with neuronal loss. Our data indicate that in some cases, NFT are not removed from the brain throughout the disease process. This finding, together with our previous demonstration of carbonyl-related modifications in NFT, provides additional evidence that the protein constituents of NFT are resistant to proteolytic removal, possibly as a result of extensive cross-links. Additionally, correlation between the number of NFT and neuronal loss indicates that there are at least two distinct mechanisms responsible for neuronal death in Alzheimer's disease that are directly and indirectly related to the presence of neurofibrillary pathology.
在本报告中，我们定量评估了一系列阿尔茨海默病患者及对照者大脑中细胞内和细胞外神经原纤维缠结（NFT）的数量，并将这些数量与神经元丢失情况进行关联分析。我们的数据表明，在某些情况下，整个疾病过程中NFT并未从大脑中清除。这一发现，连同我们之前对NFT中羰基相关修饰的证明，进一步证明NFT的蛋白质成分对蛋白水解清除具有抗性，这可能是广泛交联的结果。此外，NFT数量与神经元丢失之间的相关性表明，在阿尔茨海默病中至少有两种不同机制导致神经元死亡，这些机制与神经原纤维病理的存在直接或间接相关。
