Inagaki T, Ishino H, Seno H, Yamamori C, Iijima M
Department of Psychiatry, Shimane Medical University, Japan.
Jpn J Psychiatry Neurol. 1994 Mar;48(1):85-9. doi: 10.1111/j.1440-1819.1994.tb03001.x.
Argyrophilic glial cytoplasmic inclusions were observed in astrocytes (Astrocytic Inclusions) in a case of progressive supranuclear palsy (PSP). The inclusions were predominantly distributed in the lenticular nucleus and midbrain, but not in the cerebral cortex, white matter nor in the thalamus. When examined by double staining with Gallyas silver and GFAP, they resembled the neurofibrillary tangles (NFT) and were tau positive. The distribution of these inclusions was not related to that of NFT. These inclusions indicate that astrocytes were involved in the same pathological changes as NFT. Argyrophilic inclusions were also observed in oligodendroglias on Gallyas silver staining. They appeared coiled and located mainly in the cerebral and cerebellar white matter.
在一例进行性核上性麻痹（PSP）中，在星形胶质细胞中观察到嗜银性胶质细胞质包涵体（星形细胞包涵体）。这些包涵体主要分布在豆状核和中脑，但不在大脑皮层、白质或丘脑中。当用Gallyas银染和GFAP双重染色检查时，它们类似于神经原纤维缠结（NFT）且tau蛋白呈阳性。这些包涵体的分布与NFT的分布无关。这些包涵体表明星形胶质细胞参与了与NFT相同的病理变化。在Gallyas银染中，少突胶质细胞中也观察到嗜银性包涵体。它们呈卷曲状，主要位于大脑和小脑白质中。
