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[抗自由基保护酶在急性实验性胰腺炎治疗中的应用]

[Use of anti-radical protection enzymes in the treatment of acute experimental pancreatitis].

作者信息

Rusakov V I, Shepelev A P, Svechnikova L V, Bubnova V I, Furs L N, Chernogubova E A, Kalmykova Iu A

出版信息

Klin Khir (1962). 1993(5):45-7.

PMID:7933864
Abstract

Effect of the complex of antiradical enzymes (superoxide dismutase and catalase in proportion 1:3) was studied on the experimental mode of acute pancreatitis. After thrice repeated administration of a complex of enzymes, antioxidant capacity of the blood serum normalized, activity of the enzymes of antioxidant protection of an organism and that of glucose-6-phosphate dehydrogenase increased, concentration of extra-erythrocytic hemoglobin decreased, contributing to normalization of morphologic structure of the pancreas in 52% of the animals with hemorrhagic and in 70%--with oedematous form pancreatitis. The results obtained are indicative of possible correction of the changes in inflammatory process in the pancreas.

摘要

研究了抗自由基酶复合物(超氧化物歧化酶和过氧化氢酶按1:3比例)对急性胰腺炎实验模型的影响。在三次重复给予酶复合物后,血清的抗氧化能力恢复正常,机体抗氧化保护酶和葡萄糖-6-磷酸脱氢酶的活性增加,细胞外血红蛋白浓度降低,这有助于52%的出血性胰腺炎动物和70%的水肿性胰腺炎动物的胰腺形态结构恢复正常。所获得的结果表明胰腺炎症过程中的变化可能得到纠正。

相似文献

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Effect of antioxidant treatment in rats with acute hemorrhagic pancreatitis.
Dig Dis Sci. 1994 May;39(5):1034-40. doi: 10.1007/BF02087555.

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