Agrawal S, Matutes E, Voke J, Dyer M J, Khokhar T, Catovsky D
Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, U.K.
Leuk Res. 1994 Oct;18(10):791-5. doi: 10.1016/0145-2126(94)90062-0.
We document a case of persistent lymphocytosis in which the characteristic binucleated circulating lymphocytes were shown immunologically to be polyclonal B-cells. Cytogenetic and molecular studies failed to show a clonal population. A review of the literature on this rare condition, persistent polyclonal B-cell lymphocytosis, highlights an association with the female sex, HLA-DR7 antigen, smoking and raised levels of IgM, all of which were present in our patient.
