Plewka A, Bienioszek M, Plewka D
Department of Histology & Embryology, Silesian School of Medicine, Katowice-Ligota, Poland.
Mech Ageing Dev. 1994 May;74(1-2):79-88. doi: 10.1016/0047-6374(94)90100-7.
delta-Aminolevulinic acid synthase and heme oxygenase are closely functionally connected with the hepatic microsomal mixed function oxydase system. There is a wide range of changes in microsomal heme oxygenase activity, cytochrome P-450 level and mitochondrial delta-aminolevulinic acid synthase activity in rat livers at various stages of life. We tried to investigate the spontaneous phases of these enzymatic protein activities and the levels of cytochrome P-450 as a function of age. We noted that each of these proteins change their activity and level very characteristically during the rats' lifetime. However, correlations between heme oxygenase activity, delta-aminolevulinic acid synthase activity and cytochrome P-450 levels still need to be investigated to elucidate the mechanism of these connections.
δ-氨基乙酰丙酸合酶和血红素加氧酶与肝微粒体混合功能氧化酶系统在功能上紧密相连。在大鼠生命的不同阶段，其肝脏微粒体血红素加氧酶活性、细胞色素P - 450水平和线粒体δ-氨基乙酰丙酸合酶活性存在广泛变化。我们试图研究这些酶蛋白活性的自发阶段以及细胞色素P - 450水平随年龄的变化情况。我们注意到，在大鼠的一生中，这些蛋白质中的每一种都以非常独特的方式改变其活性和水平。然而，仍需研究血红素加氧酶活性、δ-氨基乙酰丙酸合酶活性和细胞色素P - 450水平之间的相关性，以阐明这些联系的机制。
