Nasri S, Namazie A, Dulguerov P, Mickel R
Division of Head and Neck Surgery, UCLA School of Medicine 90024-1624.
Laryngoscope. 1994 Oct;104(10):1194-8.
Forty-six patients with malignant melanoma metastatic to cervical or parotid lymph nodes with an unknown primary site were treated at UCLA Medical Center from 1964 through 1991. Treatment consisted of parotidectomy and/or neck dissection with or without adjuvant therapy. The initial presentation was a cervical mass in 74% and a parotid mass in 26% of patients. Metastasis distal to the head and neck nodal basins developed in 22% of patients. Involvement of more than four cervical or parotid nodes resulted in a significant increase in distant metastasis (P < .01). Adjuvant therapy was found to have no significant effect on survival rates. However, age at the time of diagnosis influenced the survival rates. The significance of the improved survival of these patients as compared to those with a known primary melanoma is discussed.
1964年至1991年期间，加州大学洛杉矶分校医疗中心对46例原发部位不明、伴有颈部或腮腺淋巴结转移的恶性黑色素瘤患者进行了治疗。治疗方法包括腮腺切除术和/或颈部清扫术，可辅助或不辅助治疗。初始表现为颈部肿块的患者占74%，腮腺肿块的患者占26%。22%的患者出现头颈部淋巴结区域以外的远处转移。颈部或腮腺淋巴结受累超过4个会导致远处转移显著增加（P < 0.01）。发现辅助治疗对生存率没有显著影响。然而，诊断时的年龄影响生存率。本文讨论了与已知原发性黑色素瘤患者相比，这些患者生存率提高的意义。
