Webber C E, Blake J M, Chambers L F, Roberts J G
Department of Nuclear Medicine, Chedoke McMaster Hospitals, Hamilton, Ontario, Canada.
Maturitas. 1994 May;19(1):13-23. doi: 10.1016/0378-5122(94)90037-x.
The objective of this study was to measure the effects on postmenopausal women of 2 years of either a low dose or a moderate dose regimen of hormone replacement upon bone mass and serum cardiovascular risk factors. After 6 months of calcium supplementation, 75 women chose to add hormone replacement or to remain on calcium. Those choosing hormones were randomised to either 0.3 mg/day equine estrogen and 2.5 mg/day medroxyprogesterone or 0.625 mg/day equine estrogen, days 1-25, and 5 mg/day medroxyprogesterone, days 16-25. On calcium only, lumbar spine bone mineral content and radius bone mass fell. Serum concentrations of cholesterol and triglycerides increased while HDL concentration fell. The low dose continuous regime reduced whole body bone turnover and prevented the age related reductions in bone mass and serum cardiovascular risk profile. The moderate dose regimen reduced whole body bone turnover and increased lumbar spine bone mass. Total serum cholesterol was unchanged while HDL levels increased, LDL levels fell and triglyceride concentration increased.
本研究的目的是测量低剂量或中等剂量激素替代疗法持续2年对绝经后女性骨量和血清心血管危险因素的影响。在补充钙6个月后，75名女性选择添加激素替代疗法或继续只补充钙。选择激素治疗的女性被随机分为两组，一组每天服用0.3毫克马雌激素和2.5毫克甲羟孕酮，另一组在第1 - 25天每天服用0.625毫克马雌激素，在第16 - 25天每天服用5毫克甲羟孕酮。仅补充钙的情况下，腰椎骨矿物质含量和桡骨骨量下降。血清胆固醇和甘油三酯浓度升高，而高密度脂蛋白（HDL）浓度下降。低剂量连续疗法降低了全身骨转换率，并防止了与年龄相关的骨量减少和血清心血管风险指标的变化。中等剂量疗法降低了全身骨转换率，并增加了腰椎骨量。总血清胆固醇不变，而HDL水平升高，低密度脂蛋白（LDL）水平下降，甘油三酯浓度升高。
