长期肾移植受者网状内皮系统功能的改变。

Altered reticuloendothelial function in long-term renal allograft recipients.

作者信息

Drivas G, Pulman L, Uldall P R, Wardle N

出版信息

Arch Surg. 1976 Dec;111(12):1368-71. doi: 10.1001/archsurg.1976.01360300058009.

DOI:10.1001/archsurg.1976.01360300058009

Abstract

Using the clearance of microaggregated iodinated human serum albumin reticuloendothialial system (RES) phagocytic function was tested in 48 long-term renal allograft recipients and was found to be defective at the time of testing in 70%. Depression of RES phagocytosis could be related to total steroid dosage in the previous year and to the patients liability to bacterial infections. Evidence from this test does not suggest an immunosuppressive effect of cytomegalovirus. However, three patients are discussed who have developed chronic active hepatitis that is not due to type B virus.

摘要

利用微聚集碘化人血清白蛋白清除率对48例长期肾移植受者的网状内皮系统（RES）吞噬功能进行了检测，结果发现在检测时70%的患者存在功能缺陷。RES吞噬功能的降低可能与前一年的总类固醇剂量以及患者发生细菌感染的易感性有关。该检测结果并未提示巨细胞病毒具有免疫抑制作用。然而，文中讨论了3例发生慢性活动性肝炎且并非由B型病毒引起的患者。