Drivas G, Wardle N
Metabolism. 1978 Oct;27(10):1533-8. doi: 10.1016/s0026-0495(78)80026-2.
Using clearances of microaggregated iodinated human serum albumin in a serial 'stress test,' defective phagocytosis by the Kupffer cells has been demonstrated in diabetic patients with K.W. nephropathy and proliferative retinopathy. This indicates a disturbance of phagocytic cell function that has implications for the cellular pathology of microangiopathy. The effect is not due to uremia, but could be due to T3 deficiency or lipid deposition. In hypothyroidism, there is defective RES phagocytosis, and alcoholics with hyperlipidemia can have impaired clearances. Hence, patients with advanced diabetes, hypothyroidism, and some alcoholics are at risk from infection.
在一项连续的“应激试验”中，通过微聚集体碘化人血清白蛋白的清除率，已证实在患有K.W.肾病和增殖性视网膜病变的糖尿病患者中，库普弗细胞存在吞噬功能缺陷。这表明吞噬细胞功能紊乱，对微血管病的细胞病理学有影响。这种影响并非由尿毒症引起，而可能是由于三碘甲状腺原氨酸缺乏或脂质沉积。在甲状腺功能减退症中，存在网状内皮系统吞噬功能缺陷，高脂血症的酗酒者清除率可能受损。因此，晚期糖尿病患者、甲状腺功能减退症患者和一些酗酒者有感染风险。
