Chowdhury S R, Guha S, Sen U
Department of Tumor Biology, Chittaranjan National Cancer Institute, Calcutta, India.
Neoplasma. 1994;41(3):159-61.
alpha-Difluoromethyl ornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), depletes cellular polyamine levels which is significantly correlated to neoplastic transformation. DFMO was used to modulate the growth rate of Ehrlich ascites carcinoma in mice and attempts were made to use DFMO as an adjuvant to immunotherapy. The therapeutic efficacy was estimated by measurement of polyamine levels of blood and ODC activity. Significant changes were also observed in the survival of the treated groups of animals, the implications of which have been discussed.
α-二氟甲基鸟氨酸（DFMO）是鸟氨酸脱羧酶（ODC）的抑制剂，它能降低细胞内多胺水平，而这与肿瘤转化显著相关。DFMO被用于调节小鼠艾氏腹水癌的生长速度，并尝试将DFMO用作免疫治疗的佐剂。通过测量血液中的多胺水平和ODC活性来评估治疗效果。在接受治疗的动物组的存活情况中也观察到了显著变化，并对其影响进行了讨论。
